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The Mohn Center for Precision Medicine in Diabetes (PRECISE-DIA) is seeking a full-time researcher (100%) for a 3-year position affiliated with the project “Beyond Type 1 Diabetes: Precision Medicine in HNF1B-MODY”, funded by Helse Vest for the period 2026–2028.
The project aims to functionally investigate the role of the transcription factor HNF-1B in diabetes. It is a collaboration between the Department of Pediatrics and Adolescent Medicine, Haukeland University Hospital, and the Faculty of Medicine, University of Bergen. The project is led by Professor and Senior Consultant Pål Rasmus Njølstad.
About the project
Diabetes and its complications are among the greatest global health challenges of the 21st century. One important subtype is Maturity-onset Diabetes of the Young (MODY), an autosomal dominant form of diabetes and a key example of precision medicine, which is often misdiagnosed as type 1 diabetes. Pathogenic sequence variants in the transcription factor gene HNF1B cause HNF1B-MODY, a condition that may also involve organ dysfunction, including pancreatic aplasia, kidney malformations, severe renal failure, genital malformations, and neuropsychiatric disease.
Haukeland University Hospital and the University of Bergen are internationally recognised for research into the clinical, genetic, and functional basis of monogenic diabetes. In this project, exome sequencing will be used to determine the prevalence of undiagnosed HNF1B-MODY in children and adults with presumed type 1 diabetes included in the Norwegian Childhood Diabetes Registry and the Norwegian Diabetes Registry for Adults.
Patients found to carry pathogenic variants will receive a precise molecular diagnosis, along with improved genetic counselling and treatment. They will also be invited to participate in a treatment study investigating whether insulin injections can be replaced by sulfonylurea tablets, as some patients with HNF1B-MODY respond to sulfonylureas.
Genetic data and protein function data will be integrated through multidimensional analyses and machine learning and related to clinical phenotype. This may improve prediction of diagnosis and treatment among patients with HNF1B-MODY. Functional studies of HNF1B variants will also be carried out in the world’s largest HNF1B-MODY cohort, contributing to a revision of the international diagnostic criteria for HNF1B-MODY. The project may include studies of interaction partners to the HNF-1B protein as well as biochemical and 3D-analysis of selected variants. Also, the candidate will be involved in a subproject aiming to make a high-throughput assay for investigating all theoretically possible missense variants in the HNF-1B protein (MAVE). The project is expected to have immediate impact on both diagnosis and treatment.
The position involves demanding and specialised technical and academic support functions related to research and teaching.
The successful candidate is expected to have substantial laboratory expertise in biochemical/ molecular biological methods. Advantages are experience with research on transcription factors or analyses of mutations in diabetes genes, including:
Main duties and responsilities
The position involves demanding and specialised technical and academic support functions related to research and teaching.
The successful candidate is expected to have substantial laboratory expertise in biochemical/ molecular biological methods. Advantages are experience with research on transcription factors or analyses of mutations in diabetes genes, including:
- cell and molecular biology
- cell culture, particularly beta-cell, kidney cell, and stem cell models
- protein analyses such as Western blotting and ELISA
- other relevant biological analytical methods
Required qualifications and personal attributes
Applicants must have:
- a relevant PhD, or an equivalent doctoral degree
- scientific qualifications in cell biology and molecular genetics
- interest in diabetes research
- experience in supervision, teaching, and preparation of research grant applications is desirable
- the ability to work independently and collaboratively
- strong motivation for research, a high level of work capacity, and enthusiasm for scientific work
- excellent spoken and written English skills
Experience from international collaboration is an advantage.
Personal suitability will be an important part of the overall assessment
Application requirements
The application must include:
- a motivation letter explaining your motivation, your reasons for applying, and why you are well suited for the position to be presented at an ingerview
- a CV including details of education and work experience
- certified copies of diplomas and relevant certificates/testimonials
- applicants with foreign education must submit diplomas in the original language as well as authorised translationspublications or other scientific/professional work to be considered in the evaluation (maximum 10), together with a list of these works
- the doctoral thesis in PDF format
- contact details for two referees
- Please note that all scientific works to be considered in the assessment must be uploaded in full as PDF attachments with the application
Conditions attached to the position:
The following conditions apply to the Researcher position:
- the researcher will be a member of Njølstad’s research group
- the researcher is expected to contribute actively to securing external funding for the academic environment, both for own research and for colleagues, including
- funding from the Research Council of Norway (NFR), the EU, and other sources
- the researcher may participate in committees, boards, and similar bodies
- the position carries no formal teaching obligation, but the researcher is expected to supervise master’s and PhD students where this is a natural part of the research activity of the group
- the researcher may apply for promotion in accordance with applicable academic promotion regulations
- the basis for the position will cease if project funding ends; the current legislation relating to state employees, including provisions on dismissal and preferential rights for permanent employees, will apply
We offer
- a strong and stimulating research environment at the forefront of precision medicine in diabetes
- good welfare benefits
For Norwegian applicants, please apply via Webcruiter.
English‑speaking applicants may submit their application as a PDF to: pal.njolstad@uib.no
Kontaktinformasjon
Pål Rasmus Njølstad, Professor , pal.njolstad@uib.noMagne Juuhl, Assisterande klinikkleiar, magne.juuhl@helse-bergen.no
Arbeidsstad
Haukelandsbakken 15021 BERGEN
Nøkkelinformasjon:
Arbeidsgivar: Helse Bergen HFReferansenr.: 5120676369
Stillingsprosent: 100%
Engasjement
Startdato: 01.06.2026
Søknadsfrist: 07.06.2026
Om arbeidsgiveren:
Helse Bergen, Haukeland universitetssjukehus, har nærare14.000 tilsette som har som mål å gi best mogleg helsehjelp til pasientane våre, og rett opplæring til pasientar og pårørande. Kvart år behandlar vi over 900.000 pasientar og bidreg i utdanninga av fleire tusen helsearbeidarar. Forsking og innovasjon er og viktige oppgåver i sjukehuset. Les meir på www.helse-bergen.no eller facebook.
Helse Vest skal så langt som råd avspegle mangfaldet i befolkninga. Vi ønsker å rekruttere medarbeidarar uavhengig av kjønn med ulik kompetanse, fagkombinasjonar, livserfaring og perspektiv for å bidra i spesialisthelsetenesta.
A 3-year full-time position as PhD Research Fellow in Ophthalmology is available at the Centre for Eye Research and Innovative Diagnostics (CERID), Department of Ophthalmology, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo (UiO), Norway.
The position is financed by the Research Council of Norway-funded SpotMEL project, which addresses the urgent need for improved research and diagnostic tools for uveal melanoma, the most common primary malignancy of the eye and a cancer type with high metastatic potential and limited treatment options once it spreads. SpotMEL combines biologically relevant 3D tumour modelling with advanced bioimaging and data-driven analysis to generate new insight into tumour architecture and tumour–healthy tissue interactions. Most of the work will be carried out at the Centre for Eye Research within the research environment led by Professor Goran Petrovski and at the Department of Biomaterials, UiO (led by Samara), in close collaboration with Professor Hanne Scholz, and additional project partners in the Netherlands and Canada who will contribute expertise in cell biology, omics, biomaterials, bioimaging, and research data infrastructure.
Oslo University Hospital is a workplace with great diversity. We believe this is crucial for solving our tasks in the best possible way. We want this diversity to be reflected among the applicants for our positions, and we encourage all qualified candidates, regardless of background, to apply!
Job description
The fellowship will be for 3 years and will include some administrative duties related to the CERID project. The purpose of the fellowship is research training leading to the successful completion of a PhD degree. The research fellow must take part in the University's/Faculty's/Department's approved PhD programme and is expected to complete the project within the set fellowship period. The fellowship requires admission to the PhD programme at the Faculty of Medicine, and the PhD programme application must be submitted to the department no later than 2 months after taking up the position.
For more information, see: https://www.med.uio.no/english/research/phd/index.html
The PhD candidate will develop and validate an ex vivo 3D model of uveal melanoma that better reflects the in vivo tumour microenvironment than conventional 2D cell culture. The work will focus on establishing robust 3D spheroid culture systems for uveal melanoma cells and normal choroidal melanocytes (as a biologically relevant control), and then on creating a co-culture setting that enables systematic study of the interface between tumour and healthy tissue. A central aim is to ensure the model is reproducible, well-characterised, and suitable for downstream research questions, including the evaluation of tumour–stroma interactions and features relevant to therapy development. To support biological validation and future translational use, the model will be assessed using advanced molecular biology approaches, including benchmarking of reproducibility across batches and, where applicable, testing with patient-derived material in close collaboration with clinical partners. The candidate will also be expected to document protocols and datasets in a structured way and contribute to open science practices aligned with FAIR data principles.
Qualifications
The CERID has a strategic ambition to be a leader in eye- and vision-related research in Norway and internationally. Candidates for these fellowships will be selected in accordance with this, and they are expected to be in the upper segment of their class in terms of academic credentials.
- Master's degree or equivalent in biomedical sciences, biology, biotechnology, molecular/cellular biology, tissue engineering, biomaterials, medical engineering, medicine or related fields
- Foreign completed degree (M.Sc.-level) corresponding to a minimum of four years in the Norwegian educational system
- You should have solid practical, preferably documented, experience with mammalian cell culture and sterile laboratory work.
Grade requirements:
- The average grade point for courses included in the Bachelor's degree must be C or better in the Norwegian educational system
- The average grade point for courses included in the Master's degree must be B or better in the Norwegian educational system
- The Master's thesis must have a grade of B or better in the Norwegian educational system
- Fluent oral and written communication skills in English http://www.mn.uio.no/english/research/phd/application/application.html
When evaluating the application, emphasis will be placed on the applicant's academic and personal prerequisites for carrying out the project. The top-ranked applicants will be invited to an interview.
Formal regulations
Please see the information for Research Fellowships at the University of Oslo.
No one can be appointed for more than one PhD Research Fellowship period at the University of Oslo.
According to the Norwegian Freedom and Information Act (Offentleglova), information about the applicant may be included in the public applicant list, even if the applicant has requested non-disclosure. The appointment may be shortened/given a more limited scope within the framework of the applicable guidelines on account of any previous employment in academic positions.
The University of Oslo has a policy for all employees that aims to secure rights to research results and related materials.
The application must include
- Application letter
- CV (summarising education, positions and academic work - scientific publications)
- Copies of the original Master's degree diploma, transcripts of records and letters of recommendation
- Documentation of English proficiency
- A brief account (one page, as a separate file) of the applicant's interest and motivation for applying for the position
- Publications and academic work that the applicant wishes to be considered by the evaluation committee
- Names and contact details of 2-3 references (name, relation to candidate, e-mail and telephone number)
We are offering
- Salary depending on qualifications, in a position as PhD Research fellow
- Attractive welfare benefits and a generous pension agreement
- Vibrant international academic environment
- Oslo's family-friendly surroundings with their rich opportunities for culture and outdoor activities
Kontaktinformasjon
Øystein Kalsnes Jørstad, Head of R&D Section, Professor, +4793205439, oeyjoe@ous-hf.noGoran Petrovski, Head of Research Group, Professor, +4792226158, gopetr@ous-hf.no
Arbeidssted
Kirkeveien 1660450 Oslo
Nøkkelinformasjon:
Arbeidsgiver: Oslo universitetssykehus HFReferansenr.: 5125736882
Stillingsprosent: 100%
Engasjement
Startdato: 31.08.2026
Sluttdato: 31.08.2029
Søknadsfrist: 31.05.2026
Om arbeidsgiveren:
Sammen med pasienten utvikler vi morgendagens behandling
Oslo universitetssykehus med våre 25 000 medarbeidere skal være en lærende og skapende organisasjon med evne til å tenke nytt. Vi skal ha en ledende rolle i utvikling av forskning og innovasjon, samt utvikling av morgendagens helsetjeneste, medisinsk behandling og presisjonsmedisin. Hos oss finner du noen av landets ledende eksperter innen sine fagfelt, og her blir du en del av Norges største helsefaglige arbeidsplass. Et inkluderende arbeidsmiljø preget av åpenhet og respekt er svært viktig for oss. Uansett hva du jobber med vil du få muligheten til å utvikle deg og benytte din kompetanse på et sted hvor det virkelig teller.