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A 4-year position (75 %) PhD fellowship is available at the Institute of Clinical Medicine, University of Oslo. The position will be based at the Department of Rheumatology, Oslo University Hospital (supervisor Marthe Mæhlen MD. PhD) and in close collaboration with Rasmus Iversens lab at Department of Immunology. Both Mæhlen and Iversen are affiliated with K.G. Jebsen center of Specific Autoimmune Therapy (J-SAT).
Start date will be 01.11.2026.
The research group focuses on B-cell targeting therapies in autoimmune connective tissue disorders (CTD), with special interest in myositis and the antisynthetase syndrome. In light of recent medical advances with the use of CAR-T and Bi-specific T-cell engagers in autoimmune diseases, the interest in safety and efficacy of well-known B-cell depleting therapies is increasingly relevant. Identifying risk factors for therapy-related decreases in immunoglobulins, as well as changes in auto-antibody levels in relation to disease activity is
highly sought after. Moreover, identifying autoantigen-specific B cells is a prime target for future drug therapies in autoimmune diseases.
The current project will be structured in two parts:
I) Analyses of immunoglobulins and autoantibodies, and their correlations to outcome, in a well-established large cohort of CTD patients subjected to B-cell depleting therapy with rituximab (and other immunosuppressant drugs).
II) Plan and lead a pilot study on patients with antisynthetase syndrome in the Department of Rheumatology as well as lab-based research on subsets of B-cells from these patients.
The position will be part-time (75 %) over 4 years to provide sufficient time for completion of the pilot study within the timeframe of the PhD period. As the project involves clinical follow-up of patients with connective tissue disorders, we encourage the candidate to hold a part-time clinical position (i.e. 25 %) in rheumatology.
Qualification requirements
Preferred skills
We are looking for a PhD candidate with
Employment in the position is based on a comprehensive assessment of all qualification requirements applicable to the position, including personal qualifications.
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Your application should include:
Application with attachments must be submitted via our recruitment system Jobbnorge, click "Apply for the position".
When applying for the position, we ask you to retrieve your education results from Vitnemålsportalen.no. If your education results are not available through Vitnemålsportalen, we ask you to upload copies of your transcripts or grades. Please note that all documentation must be in English or a Scandinavian language.
The best qualified candidates will invited for interviews.
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The University of Oslo has a transfer agreement with all employees that is intended to secure the rights to all research results etc.
Om arbeidsgiveren:
The University of Oslo is Norway’s oldest and highest ranked educational and research institution, with 26 500 students and 7 200 employees. With its broad range of academic disciplines and internationally recognised research communities, UiO is an important contributor to society.
The Institute of Clinical Medicine (Klinmed) is one of three institutes under the Faculty. Klinmed is responsible for the Faculty's educational and research activities at Oslo University Hospital and Akershus University Hospital. With about 900 employees spread over approximately 425 man-labour years, Klinmed is the university's largest institute. Our activities follow the clinical activity at the hospitals and are spread across a number of geographical areas.
